但是在這份申請書中 , 洩漏了許多細節都讓人懷疑 在TA1要做什麼? 申請文件寫 We will sequence their spike protein, reverse engineer to conduct binding assays, and inset them into bat SARSr- CoV (WIV1, SHC014) backbones (these use bat-SARSr-CoV backbones, not SARS-CoV, and are exempt from dual use and gain of function concerns) to infect humanized mice and assess capacity to cause SARS-like disease. 我們將對它們的刺突蛋白進行測序,逆向工程進行結合測定,並將它們插入蝙蝠 SARSr-CoV(WIV1、SHC014)骨架(這些使用 蝙蝠bat-SARSr -CoV 骨架,而不是 SARS-CoV,並且免於雙重用途和功能增強)感染人源化小鼠並評估引起 SARS 樣的疾病
在 TA2 中, Peter Daszak說將評估兩種減少洞穴蝙蝠 SARSr-CoV 排毒的方法: (1) Broadscale immune boosting, in which we will inculated bats with immune modulators to upregulate their innate immune response and downregulate viral replication; (1)大規模免疫增強,我們將給蝙蝠接種免疫調節劑,以上調它們的先天免疫反應並下調病毒複製; (2) Targeted immune boosting in which we will inoculate bats with novel chimeric polyvalent recombinant spike protein plus the immune modulator to enhance innate immunity against specific,high- risk viruses. 標靶免疫增強,我們將用新型嵌合多價重組刺突蛋白和免疫調節劑接種蝙蝠,以增強對特定高危險病毒的先天免疫。 We will trial inoculum delivery methods on captive bats including novel automated aerosolization system, transdermal nanoparticle application and edible adhesive gels 我們將在圈養蝙蝠上試驗接種遞送方法,包括新型自動噴霧氣化系統、穿透皮膚納米顆粒應用和可食用粘性凝膠。 We will use stochastic simulation modeling informed by field and experimental data to characterize viral dynamics in our cave test sites, maximize timing, inoculation protocal, delivery method and efficacy of viral suppression. The most effective biologicals will be trialed in our test cave site in Yunnan Province, with reduction in viral shedding a proof-of-concept. 我們將使用由現場和實驗數據提供信息的隨機模擬模型來表徵我們洞穴測試地點的病毒動力學,最大限度地提高病毒抑制的時間、接種方案、遞送方法和功效。最有效的生物製品將在我們雲南省的測試洞穴中進行試驗,減少病毒排毒是一個概念證明。 novel automated aerosolization system, transdermal nanoparticle application and edible adhesive gels 接種遞送方法,包括新型自動噴霧氣化系統、穿透皮膚納米顆粒應用和可食用粘性凝膠
之前的冠毒明明是飛沫傳染,居然2018年 , Peter Daszak 的申請書就提及 能以空氣噴霧來傳染 ? 申請書 也明白寫了 , The most effective biologicals will be trialed in our test cave site in Yunnan Province, 最有效的生物製劑將在我們的雲南省試驗洞穴現場進行試驗 雲南省試驗洞穴? 和2012年6名礦工肺炎有無關聯? Dr. Shi, Wuhan Institute of Virology will conduct viral testing on all collected samples, binding assays and some humanized mouse works. 武漢病毒所石博士將對所有採集的樣本進行病毒實驗、結合試驗和部分人源化小鼠工作。 『人源化小鼠』? 是帶了人類基因的小鼠 , 能感染人類的病毒 如果 SARS2 一躍從蝙蝠跳到人身上並且此後沒有太大變化,它應該仍然擅長感染蝙蝠。但似乎不是。 “經過測試的13種蝙蝠, 只有其中2種蝙蝠能被 SARS-CoV-2 感染,而且病毒對蝙蝠細胞的結合能力? 親合力只有對人類細胞的1/10 ? 因此它們不太可能成為人類感染的直接來源,也沒有找到那一個蝙蝠族群是 Covid-19(SARS-CoV-2病毒)的保毒者 ? RaTG13 從一個蝙蝠病毒 → 人類病毒 , 怪得是下游病毒 SARS CoV 2 卻和蝙蝠的親合力很差 ?
I, of sound mind and body, do not suffer from any chronic illnesses of either a physical or mental nature, and will therefore incontrovertibly refrain from all suicidal actions or any events that may be thus construed.
I do not suffer from insomnia, and therefore do not and will not take sleep- inducing medication of any kind.
I am not an alcoholic and am not a user of any illicit drugs or other illegal substances.
I have never and will never venture in the vicinity of the following:
1. Open waters.
2. Swimming pools where a lifeguard is not present.
3. Places where high-pressured or hazardous gases are present, or basements or water storage facilities lacking proper ventilation.
4. Any elevated location where no proper safety rails or safeguards are present.
5. Any construction site (except those pertaining to the demolishing of the government), including sites where breakwater blocks are made.
6. Any site or locale not covered in the above criteria, but is nevertheless not where normal persons of sound mind and body will enter.
I have and will always adhere strictly to the following:
1. I will thoroughly inspect my vehicle for any faults or malfunctions before driving, and will turn off the power on my vehicle and on my cell phone before refueling.
2. I will never run a red light, nor accelerate past a yellow light.
3. When taking any form of rail transport, before the train has come to a complete stop, I will always retreat to a distance of at least one step behind the waiting line.
4. When riding a motorcycle, I will always wear a certified helmet; when driving or riding in a car, I will always wear a seat belt.
5. I will never venture near any locale or equipment where radiation poses an immediate risk to the human body (for example, nuclear power plants).
6. I will never head into the mountains or to the seashore during typhoons or otherwise stormy weather.
I have and will always do my utmost to adhere to safety standards when using appliances and equipment powered by electricity, natural gas, or fire.
The electrical wiring in my residence is in compliance with relevant regulations, and has not nor will ever be the cause of a fire.
I have and will never store excessive amounts of flammable gases or liquids in my residence.
My bathrooms are free of all electric appliances, except necessary lighting.
Before sleeping, I always turn off all electric appliances, except any necessary lighting, the refrigerator, and electric fans.
I have and will never engage in disputes or clashes, physical or otherwise, with persons with whom I am not acquainted. Moreover, I have and will always strive to ensure my personal safety.
If, after being notified of the above, my fellow netizens discover that this ID has disappeared from online activity for a substantial amount of time, please do all in your means to seek justice for me. Thank you.