Then in 2007, Yiu Wing Kam et al. explored whether antibody against SARS-CoV viral spike protein can induce viral entry into FcR-bearing cells and evoke ADE (Kam et al., 2007). The results showed that these antibodies increase the affinity of SARS-CoV towards FcγRII-bearing cells.
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spartamimi wrote:
滅活疫苗和mRNA或重組疫苗不同(它們只有S蛋白),滅活疫苗是使用完整的病毒弱化而成,所以除了Spike蛋白,還有其它病毒蛋白如膜蛋白.可是只有Spike蛋白會產生中和抗體,這是我們要的,它能阻斷病毒入侵我們的細胞,其它蛋白會則產生非中和抗體,它們不能阻止病毒入侵,但會吸引其它免疫細胞如巨噬細胞吞噬病毒.