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驚!兒科常用退燒藥水竟然會造成巴比妥偽陽性!!

https://pubmed.ncbi.nlm.nih.gov/2323039/
======================
Clin Chem . 1990 Apr;36(4):602-6.
Investigation of interference by nonsteroidal anti-inflammatory drugs in urine tests for abused drugs

Abstract
Anecdotal and uncontrolled studies have suggested that nonsteroidal anti-inflammatory drugs produce false-positive results in immunoassay urine tests for some drugs of abuse. This study was performed in 60 volunteers who took ibuprofen as either a single 400-mg dose, or 200 mg three times a day, or 400 mg three times a day, and in 42 patients taking ibuprofen, naproxyn, or fenoprofen in therapeutic regimens for more than 30 days. Of the 510 urines collected from 102 individuals during these dosage regimens, two gave false-positive tests for cannabinoid by enzyme-mediated immunoassay (EMIA), one after 1200 mg of ibuprofen in three divided doses for one day and one in a patient taking naproxyn on a chronic basis; none was falsely positive for benzodiazepines. Two urines were false-positive for barbiturates by fluorescence polarization immunoassay (FPIA), one in a patient taking ibuprofen and one in a patient taking naproxyn. These data, collected prospectively, demonstrate the small likelihood of a false-positive immunoassay test result for cannabinoids, benzodiazepines, or barbiturates after the acute or chronic ingestion of ibuprofen, or after the chronic ingestion of naproxyn or fenoprofen.
========================
新聞中檢察官一直找不到用藥來源
新聞中園長兒子也陽性
新聞中彩虹藥水是一般的感冒藥水

理組長眉頭一皺,試著找出其他可能
文獻中果然有所發現
偽陽性不無可能

These 10 Medications Can Cause a False Positive on Drug Tests

https://www.goodrx.com/drugs/side-effects/these-medications-can-cause-a-false-positive-on-drug-tests
這裡的圖表也有說明

到底事實如何,風向會如何變化,讓我們繼續看下去
2023-06-10 17:19 發佈
隨便講講 wrote:
文獻中果然有所發現
偽陽性不無可能

那幼兒園不就要喊冤了?
Blues0722

都動用到質譜儀了, 這樣你還能扯淡!

2023-06-19 16:49
old_hsiao

幼兒園早就喊冤了,只是豬哥黨強力操弄,沒人要聽幼兒園的話。

2023-06-20 22:58
https://www.uspharmacist.com/article/urine-drug-screening-minimizing-false-positives-and-false-negatives-to-optimize-patient-care
========
這篇的圖表也做得很清楚
Naproxen , ibuprofen. 都是止痛退燒藥
隨便講講 wrote:
https://pubmed...(恕刪)


侯粉開始崩潰了,要趕快找到解決之道
剛進股市的萌萌噠小白,請大家多多關照。
帕達鴨

當初瘋狂咬是毒品的,不就是柯粉

2023-06-11 8:16
星海之城

巴比妥確實是毒品成分...俗名:紅中、青發十年前毒品市場很常見

2023-06-20 20:05
隨便講講 wrote:
https://pubmed...(恕刪)
不是這樣補腦吧,與其辛苦找外國英文文獻,來佐證國內用藥的情形,不說沒太大參考價值,,根本是把國內中文醫藥文獻,按在地板摩擦,你直接拿他所謂的彩虹藥水去化驗,不就知道了

其實,衛福部食藥署應該是最有資格說話的,因為原料藥、成藥都是他管的,有無巴比妥,食藥署最清楚,在資料庫裏面都有。

但,DPP檢調也很奇怪,不敢公布園方餵食的所謂感冒藥水是哪個牌子或是有無處方簽,只要成藥,自然會有原廠出來說話,若是處方簽,也會有醫師出來說明。

所以,才有一堆天馬行空的猜測,過些天,說這感冒藥水,是天主給的,是天上掉下來的禮物,我也不會意外............

巴比妥對人使用有管制,對於其他動物就難說了,難怪獸醫公會出來喊冤,不關我的事............

遭暗指「幼兒園毒藥」來源獸醫院? 獸醫公會怒否認:造謠者自重
Lucky John

其實就看調查樣本中有沒有包含未使用感冒藥但是有驗出的兒童。新聞出來蠻震驚的但我不認為幼稚園會非法餵藥,沒必要且風險高。

2023-06-10 19:09
old_hsiao

衛福部就一直裝死啊。

2023-06-20 22:59
原來如此

非常感謝分享 !!

不過, 這是 1990 年的論文, 已經過去 30 年

檢測方法不曉得有沒有進步?


樓主以下這篇較新

https://www.uspharmacist.com/article/urine-drug-screening-minimizing-false-positives-and-false-negatives-to-optimize-patient-care
那年雨不停國

只能靜待後續發展

2023-06-10 17:45
Blues0722

nwcs 有些好奇, 真的有專門為動物研發的藥品嗎??

2023-06-19 16:53
,樓主好認真
2010 Aug 15;67(16):1344-50. doi: 10.2146/ajhp090477.
Commonly prescribed medications and potential false-positive urine drug screens

Summary: A comprehensive literature review was conducted to identify false-positive UDSs associated with all clinic formulary medications, as well as common nonprescription medications. The references of each report describing a medication whose use was associated with false-positive UDS results were also reviewed. If a class effect was suspected, additional agents in the category were searched. A total of 25 reports of false-positive UDS results were identified. Categories of medications included antihistamines, antidepressants, antibiotics, analgesics, antipsychotics, and nonprescription agents. Reports of false-positive results were found for the following formulary and nonprescription medications: brompheniramine, bupropion, chlorpromazine, clomipramine, dextromethorphan, diphenhydramine, doxylamine, ibuprofen, naproxen, promethazine, quetiapine, quinolones (ofloxacin and gatifloxacin), ranitidine, sertraline, thioridazine, trazodone, venlafaxine, verapamil, and a nonprescription nasal inhaler. False-positive results for amphetamine and methamphetamine were the most commonly reported. False-positive results for methadone, opioids, phencyclidine, barbiturates, cannabinoids, and benzodiazepines were also reported in patients taking commonly used medications. The most commonly used tests to screen urine for drugs of abuse are immunoassays, even though false-positive results for drugs of abuse have been reported with a number of these rapid-screening products. Results from such tests should be confirmed using additional analytical methods, including gas chromatography-mass spectrometry.
======
那就再來一篇

只是提供一個其他思路
坐等最後更進一步的檢驗結果出來
其實有些感冒藥水,裡面是有嗎啡成分的

過去新聞報過,就是有人喝了被驗出毒品反應,還有人帶好幾瓶感冒藥被海關依走私毒品罪抓走

我上個月染疫去看醫生,他也是開含啊片的藥水給我,據說還有人可以在藥房買到
ohmoto_tw

你說的就是常用的甘草止咳藥水,裡面含有阿片酊。https://www.medpartner.club/cough-syrup-child-myth/

2023-06-11 12:02
blood0819

含鴉片類的藥水在注意事項上都會寫具成癮性,只是老一輩長期以來的用藥習慣是…呼乾啦,感冒糖漿經常都是採罐耶,一天好幾罐。之前還有個新聞「感冒藥被當吸毒 勒戒冤獄判賠26萬」

2023-06-29 16:19
幼稚園餵的藥,應該是家長帶小孩看醫生後,醫生開的處方。新北的家長應該很少買成藥給小孩吃,更不會由園方統一備藥吧。

應該追溯孩童就醫紀錄,把醫生用的藥拿來檢查。如果用藥和驗出結果不同,就是園方的問題。
ray0616

嗯, 邏輯觀念明確, 完全同意!問題是在台灣政壇都是北七嗎? 這樣"循規蹈矩"去查, 就不能陰對方了!!鬼島, 別奢望黑白是非對錯了

2023-06-19 16:22
Blues0722

RentHA 有人就是要把「彩虹藥水」導向是混了一堆不同顏色的藥水!!

2023-06-19 16:55
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