大家好
最近看到新聞有這家的消息, 請問這家若上櫃, 可以買嗎? 多謝
目前的肝癌靶標藥 Nexavar, 是讓血管不會連接到肝癌細胞上, 讓肝癌細胞餓死, 但 ADI-PEG 20 雖然也是讓 肝癌細胞餓死, 但方法不同, 是先將身體裡面的一種營養給全殺掉, 但好的細胞過幾天就會自己製造一樣的東西, 所以不會受影響, 但癌細胞沒有這本事, 所以就死定拉
目前的存活率比 Nexavar 好, 請問目前若三期的測驗過, 就可以在美國, 歐洲 當然還有亞太賣, 以前 Nexavar 自費要一顆1500台幣, 一天要4顆, 好像滿好賺的
請問有大大有比較詳細的資料嗎
多謝
The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials.
INTRODUCTION:
The metabolic differences between normal, healthy cells and neoplastic cells have been exploited by anticancer therapies targeting metabolic pathways. Various studies of malignant processes have demonstrated disturbances in both arginine synthesis and metabolism that enhance or inhibit tumor cell growth. Consequently, there has been an increased interest in the arginine-depleting enzyme arginine deiminase (ADI) as a potential antineoplastic therapy.
AREAS COVERED:
This review summarizes the literature on the potential anti-cancer therapeutics arginine and ADI, an arginine-catabolizing enzyme. The authors searched the MEDLINE database PubMed using the key words: 'arginine, 'ADI', 'arginine in cancer' and 'ADI and cancer'. The authors evaluate prospective randomized studies on cancer patients between 2004 and 2013 as well as ongoing research found through the US National Institutes of Health trial database.
EXPERT OPINION:
The results of current studies are promising but do not give unequivocal answers and so it is impossible to recommend arginine or its enzyme ADI as a therapeutic. In the opinion of the authors, further identification of arginine-dependent malignant tumors and their metabolism should be investigated. Furthermore, the use of these chemicals, in combination with other chemotherapeutics drugs, should be investigated and indeed may improve the success of arginine-depleting enzymes such as pegylated ADI (ADI-PEG20).
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