United States Patent 8,268,969
Wong , et al. September 18, 2012
Globo H and related anti-cancer vaccines with novel glycolipid adjuvants
Abstract
Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an .alpha.-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM197.
United States Patent 9,028,836
Wong , et al. May 12, 2015
Globo H and related anti-cancer vaccines with novel glycolipid adjuvants
Abstract
An immunogenic composition containing a glycan conjugate including a carrier protein, and a glycan including Globo H, an immunogenic fragment thereof, or stage-specific embryonic antigen-4 (SSEA-4), wherein the glycan is conjugated with the carrier protein through a linker.
Inventors: Wong; Chi-Huey (Taipei, TW), Wu; Chung-Yi (Taipei, TW), Yu; Alice L. (Taipei, TW), Yu; John (Taipei, TW)
Applicant:
Name City State Country Type
Wong; Chi-Huey
Wu; Chung-Yi
Yu; Alice L.
Yu; John
Taipei
Taipei
Taipei
Taipei
N/A
N/A
N/A
N/A
TW
TW
TW
TW
因為人體的NK cell極可能要同時看到golobo H isotype及KLH isotype時才會啟動攻擊....
如此一來，822就只能在很短時間內發揮一點點作用。
是故，可以合理解釋822的臨床根本達不到預期的療效。
...
同時，前述人體MHC class I inhibition 又非常關鍵的壓抑了822的效果。
...
最後結論是：822只能達到極短期效果，癌細胞最後還是輕易躲過了822的防線。822立即宣告失效！
jeffreywen2010 wrote:
張董乾脆宣佈說開這...(恕刪)
炒股第一定理:
自己相不相信不重要!
市場相不相信才重要!
直到泡沫破掉
看來"許多大咖"一直相信解盲將成功
解盲失敗後仍有大部位未出脫
董事長惹不起
只好繼續說好話安撫
對部份病患有效?
我想公司也永遠無法確認是哪些狀況下的病患有效
人體生理運作機制是成千上萬的激素酵素共同運作的結果
此機制也不是線性關係
但是人類的科學解析,卻是用線性的規則來分析
沒抓到keypoint 在瞎子摸象
以電影模仿遊戲來說好了
台灣的生技股的解盲
就像男主角圖靈的破解Enigma加密機解碼團隊的"其他成員",
用猜字謎或西洋旗的思考方式來破解(猜字高手與西洋棋冠軍),看起來很有進度
唯男主角毫無動靜,被其他成員嘲笑
圖靈謀靜後動,最後卻是靠他發明的計算器破解Enigma,結束二次大戰!
台灣那些炒得火熱的生技股公司就是圖靈的同事,不得要領! 沒有抓到keypoint, 看圖說故事
該公司說解盲的資料可看出部份有效,
好像電影中圖靈猜字謎高手同事發現某天的所有電文譯碼看出規則了,
但是到了隔天以後,Enigma Reset各齒輪,規則又都失效!
炒個解盲很可能成功
生技股飆漲倒貨給散戶
這金光黨最高明之處,就是他是合法的,不用跑路!
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