Garmin GPSMAP 62s advantages Brighter screen in a wider range of conditions Menu items faster and easier to access May be slightly more rugged Longer rated battery life (20 hours vs. 16 for the Oregon 450) Better for mountain bikers and others needing to easily change pages on the fly Reception may be better in vertical orientation due to quad-helix antenna (untested) Buttons (instead of touch screen) – a personal preference issue
Garmin Oregon 450 advantages Larger screen Higher resolution Better for auto use (due to touch screen) Text entry (entering waypoint names, etc.) faster on touch screen More mature firmware Better discounts available (this should change over time) Significantly lighter (6.8 oz. with batteries vs. 9.2 for the 62s) Easier to switch data fields Touch screen – a personal preference issue